Aspirin Resistance: Clinical Significance and Genetic Polymorphism
نویسندگان
چکیده
منابع مشابه
Resistance to aspirin and clopidogrel: possible mechanisms, laboratory investigation, and clinical significance.
grel treatment in patients with coronary artery disease is well documented. However, recent studies that investigated the in vitro response of platelets to the administration of these drugs showed this response to be variable. Some patients have been observed to exhibit nonresponsiveness or resistance, thus having an increased risk of thrombotic episodes. So far, there is no generally accepted ...
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Salicylates have been used to treat pain and inflammation associated with rheumatism and other conditions since ancient times. The Assyrians initially described the use of willow leaves in treating rheumatism (1). This practice was continued into the 19th century when the first scientific studies evaluating this remedy were published in Europe. The active ingredient, salicylic acid, was first d...
متن کاملAspirin and clopidogrel resistance: an emerging clinical entity.
Antiplatelet therapy is a cornerstone of cardiovascular medicine. Aspirin and clopidogrel have emerged as critical therapies in the treatment of cardiovascular disease. Despite their efficacy, patients on these medications continue to suffer complications. Millions of patients are currently on low-dose antiplatelet therapy but it is unknown how many of these patients are under-treated or on the...
متن کاملDiabetes and Aspirin Resistance
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in patients with diabetes mellitus (DM). DM is considered as a coronary artery disease equivalent for future risk of vascular events. There are 3 different classes of platelet-inhibiting drugs: cyclooxygenase-1 (COX-1) inhibitors (aspirin), ADP P2Y12 receptor antagonists (thienopyridines), and platelet glycoprotein (GP...
متن کاملAspirin and clopidogrel resistance.
Aspirin and clopidogrel provide significant clinical benefit in patients with cardiovascular disease. However, given the complexity of platelet activation, it is not surprising that aspirin or clopidogrel prevent a small proportion of cardiovascular events. Of late, the terms aspirin and clopidogrel "resistance" have entered the physicians' lexicon, and infer a lack of therapeutic response and ...
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ژورنال
عنوان ژورنال: Journal of International Medical Research
سال: 2012
ISSN: 0300-0605,1473-2300
DOI: 10.1177/147323001204000128